2022 Fiscal Year Final Research Report
Interaction between Enteric Nervous System and Immune System in the Pathogenesis of Systemic Lupus Erythematosus
| Project/Area Number |
20K08779
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
|
|---|
| Research Institution | Dokkyo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
有馬 雅史 獨協医科大学, 医学部, 教授 (00202763)
幡野 雅彦 千葉大学, 大学院医学研究院, 教授 (20208523)
倉沢 和宏 獨協医科大学, 医学部, 教授 (30282479)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | NCX / Autoimmune disease / Rheumatoid arthritis |
|---|
| Outline of Final Research Achievements |
Dysbisosis with increased nitric oxide (NO) production are induced in the intestinal tract of mice lacking (KO) the homeobox gene Ncx. To elucidate the function of Ncx in autoimmune diseases, we analyzed Ncx-KO mouse models of autoimmune diseases using the SKG mouse genotype as a background and found that Ncx was not involved in the pathogenesis of SLE models, but in RA models, increased Tregs and decreased IL-17 producing T cells in the colonic LPL of KO mice were associated with reduced arthritis. Although the pathological significance of Ncx in arthritis in SKG mice is not clear, the production of intestinal NO may be involved in the reduction of RA-like arthritis through conversion of arthritis-induced dysbiosis.
|
| Free Research Field |
Rheumatology
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は，SLEなど自己免疫疾患の新規治療法の開発に大いに貢献し，さらに様々な免疫性疾患の病態の分子メカニズムの解明することに学術的意義がある．また新規分子標的治療法の開発へとつながる点に社会的意義がある．
|
