2022 Fiscal Year Final Research Report
Improvement of IgG4-related disease model and its treatments
| Project/Area Number |
20K08801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | IgG4 / IgG4関連疾患 / モデルマウス / IgGサブクラス / MRL/lprマウス / 形質細胞 / T細胞 |
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| Outline of Final Research Achievements |
IgG4 is an IgG subclass that can exhibit inhibitory functions under certain conditions. Although several diseases have been associated with IgG4, its role remains unclear. Since mice do not express an identical IgG subclass to human IgG4 (hIgG4), hIGHG4 knock-in (KI) mice were generated and analyzed. To enhance the production of IgG4, an MRL/lpr-IgG4KI mice model was established by backcrossing. These mice showed a high IgG4 concentration in the sera and increased populations of IgG4-positive plasma cells and CD3+B220+CD138+ T cells in the spleen. Moreover, these mice showed aggravated inflammation in organs such as the salivary glands and stomach. The MRL/lpr-IgG4KI mouse model might be useful for studying IgG4-related disease and allergic diseases.
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| Free Research Field |
膠原病学
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| Academic Significance and Societal Importance of the Research Achievements |
IgG4型自己抗体は、いくつかの自己免疫疾患において病原性を示す。一方、IgG4は、免疫制御M2マクロファージの機能を促進することにより、食物アレルギーに対する防御に関連している。我々は本マウスモデルにおいてIgG4型抗体が誘導されることを証明した。今回確立したマウスモデルは、アレルギー性疾患、IgG4-RD、IgG4型抗体関連疾患（天疱瘡、重症筋無力症、特発性膜性腎症、血栓性血小板減少症など）の病態生理を解明するために使用できる。
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