2023 Fiscal Year Final Research Report
Analysis of Gastric Carcinogenesis Mechanisms Focusing on TLR10 Diversity
| Project/Area Number |
20K08824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54030:Infectious disease medicine-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 聡 札幌医科大学, 医学部, 助教 (10588479)
加藤 淳二 札幌医科大学, 医学部, 教授 (20244345)
白石 宗 札幌医科大学, 医学部, 助教 (70725168)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Toll like receptor / LPS / Helicobacter pylori / Anti-inflammatory |
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| Outline of Final Research Achievements |
We have focused on the structure of Helicobacter pylori (H. pylori) LPS and reported that it is recognized by Toll like receptor 10 (TLR10), and demonstrated that TLR10 influences gastric cancer development and the degree of gastritis in H. pylori infection. We have also demonstrated that, unlike other TLRs, signals from TLR10 show an anti inflammatory response, and that similar responses are observed in Bacteroides, Akkaremansia, and other genera in addition to the LPS of H. pylori.
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| Free Research Field |
自然免疫
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| Academic Significance and Societal Importance of the Research Achievements |
LPSは菌の種類によって多様な形態をとるが、常在菌におけるLPSに共通の構造がTLR10に認識されている可能性を示唆する結果を得た。これまでの不明とされていたTLR10のリガンドは、実は体内に多量に存在しており、その免疫反応もAnti-inflammatoryな反応が中心であった。学術的な意義としては今後IBSやirAE腸炎などの治療薬の開発につながる可能性を示唆する結果と考えている。
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