2023 Fiscal Year Final Research Report

A trial of exercise and nutrition treatment for aged esophageal cancer patients undergoing neoadjuvant chemotherapy

Research Project

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Project/Area Number	20K09007
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55020:Digestive surgery-related
Research Institution	Kansai Medical University (2021-2023) Osaka University (2020)
Principal Investigator	YAMASAKI Makoto 関西医科大学, 医学部, 教授 (50444518)
Co-Investigator(Kenkyū-buntansha)	松浦記大大阪大学, 大学院医学系研究科, 招へい教員 (90804477) 山下公太郎大阪大学, 大学院医学系研究科, 助教 (20747159) 田中晃司大阪大学, 医学部附属病院, 助教 (70621019) 牧野知紀大阪大学, 大学院医学系研究科, 助教 (80528620) 西塔拓郎大阪大学, 大学院医学系研究科, 助教 (20646468) 高橋剛大阪大学, 大学院医学系研究科, 講師 (50452389) 黒川幸典大阪大学, 大学院医学系研究科, 准教授 (10470197)
Project Period (FY)	2020-04-01 – 2024-03-31
Keywords	高齢癌患者 / フレイル / 運動・栄養介入
Outline of Final Research Achievements	In super-aged society, there is a need to optimize cancer treatment for the elderly. This study was conducted to clarify whether exercise and nutritional intervention during preoperative treatment for elderly esophageal cancer can be safe and feasible, and improve physical function. 60 cases were registered, 30 cases each in the intervention and non-intervention groups, and the analysis of short-term outcome data was completed. The reduction rate in psoas muscle mass before and after chemotherapy, which was the primary endpoint, was significantly suppressed in the intervention group. In addition, postoperative complications were significantly reduced in the intervention group compared to the non-intervention group. This suggests that exercise and nutritional intervention during chemotherapy may be relatively safe and able to prevent a decline in physical function.
Free Research Field	上部消化管外科
Academic Significance and Societal Importance of the Research Achievements	これまでの高齢がん患者に対する治療は、高齢者の生活機能の低下を評価して、安全に（強度を弱めて）治療することを中心に開発が進められてきた。本試験の結果、新たな全身振動トレーニングとアミノ酸摂取という運動・栄養介入によって安全に身体機能を向上させることができ、かつ手術治療成績を向上させることが明らかになりました。この結果は高齢がん患者に対する治療戦略に新たな道筋になると考えられ、社会的に非常に意義のある結果である。