2022 Fiscal Year Final Research Report
Development of Novel Pancreatic Cancer Exercise Intervention Therapy by CD36 Expression Analysis
| Project/Area Number |
20K09042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高木 忠隆 奈良県立医科大学, 医学部附属病院, 研究員 (20833700)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 膵癌 / CD36 / 運動療法 |
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| Outline of Final Research Achievements |
This study focused on CD36, a fatty acid transporter that plays a central role in the cellular uptake of fatty acids and has recently been shown to be involved in the metastasis and proliferation of various cancer types. The goal of this study is to clarify the theoretical background of the effects of exercise on cancer therapy and to establish a more effective exercise load by evaluating the effects of changes in CD36 on cancer cells and cancer host.
However, it is difficult to obtain the stability of CD36 expression in experimental mice (especially, streptozocin-induced diabetic mice), and we have not yet conducted the experiment of exercise load.
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| Free Research Field |
外科学一般
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| Academic Significance and Societal Importance of the Research Achievements |
近年，集学的治療完遂や直接の予後向上を目指し様々なプロトコールで栄養や運動介入が試みられているが，運動介入によって筋力が増強・維持され，栄養療法で栄養指標が上昇しても，そのことが治療耐性や予後にいかにつながるのかは，明らかにされていない．今回着目した脂肪酸トランスポーターであるCD36は，筋肉・血管内皮・悪性腫瘍など脂肪酸を必要とする細胞に広く分布し，運動介入で発現が変化することが知られており，さらには，悪性腫瘍細胞上にもCD36が発現していることが報告されているため，介入の効果をCD36の発現変化から紐解くことができる可能性がある．
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