Establishment of a system for evaluating the anticoagulation potential of direct oral anticoagulants using a dielectric coagulometer

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09263
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Uchida Tokujiro 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40262183)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 直接経口抗凝固薬 / ポイントオブケア検査

Outline of Final Research Achievements

In this study, we measured the clotting time using a dielectric blood coagulometer (DBCM CT) on whole blood samples from healthy volunteers, spiked with coagulation factor Xa inhibitors such as apixaban, rivaroxaban, and edoxaban, as well as direct thrombin inhibitors such as dabigatran and argatroban. The results indicated that in the system where a coagulation factor X activator reagent was applied, the DBCM CT was prolonged by direct oral anticoagulants in a concentration-dependent manner. This suggests that the dielectric blood coagulometer system used in this study is useful as a point-of-care test for evaluating the anticoagulation potential of direct oral anticoagulants, including factor Xa inhibitors and direct thrombin inhibitors.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

Point of Care 型の検査機器で直接経口抗凝固薬（DOAC）の薬効が評価できるようになれば、DOACが目標に適合した薬効を発揮しているかどうか簡便かつ迅速に評価でき、患者への適切な介入が可能となる。特に緊急的に観血的な介入をしなければならない症例において、中和の適応の判断基準として役立てることができるようになり、臨床的な意義は大きいと考えられる。