2023 Fiscal Year Final Research Report
Mechanical support for right heart failure in single ventricle physiology
| Project/Area Number |
20K09266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
黒子 洋介 岡山大学, 大学病院, 講師 (20459184)
朔 啓太 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40567385)
清水 秀二 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (80443498)
笠原 真悟 岡山大学, 医歯薬学域, 教授 (90233692)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | フォンタン循環 |
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| Outline of Final Research Achievements |
A total of 6 pigs weighing 30kg were used. Fontan pathway was constructed by connecting SVC and IVC to the main PA using a handmade Y-shaped PTFE graft. Total CPA was established by both SVC and IVC draining to MPA, whereas only IVC was drained in the partial CPA. The CPA support was adjusted at half (50%) or full (100%) flow of baseline cardiac output (CO). Hemodynamic were evaluated before and after the establishment of Fontan circulation with or without CPA.
Upon the establishment of Fontan circulation, both SVC and IVC pressure significantly increased, resulting in low CO (failing Fontan circulation). With 100% support of total CPA, CO recovered at the level of baseline with SVC and IVC pressure decreased. CO increased at 80% of baseline with IVC pressure decreased by 100% support of partial CPA but SVC pressure increased above 25mmHg. 50% support of partial CPA resulted in an increase in CO about 65% of baseline with SVC pressure of 20mmHg.
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| Free Research Field |
心臓血管外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、フォンタン循環不全の際の補助循環の様式について検討したものである。フォンタン循環にて右心補助を行う際には、その解剖的な特徴から部分的な補助循環となるため、有効的な補助循環が行えるかどうか不明である。本研究では、有効的な補助循環を行うには、補助循環のサポート率の調整が必要であることが示唆され、臨床における判断基準となると考えられた。
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