2023 Fiscal Year Final Research Report
Basic research to elucidate the occurrence of inhomogeneity of transpulmonary pressure and to establish an individual ventilatory strategy for different pathological lungs.
| Project/Area Number |
20K09272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
矢澤 華子 (佐藤華子) 獨協医科大学, 医学部, 講師 (60438132)
馬場 靖子 国際医療福祉大学, 医学部, 教授 (80453041)
矢澤 卓也 獨協医科大学, 医学部, 教授 (50251054)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 人工呼吸器関連肺障害 / 肺保護戦略 / 経肺圧 / P-SILI |
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| Outline of Final Research Achievements |
The histological change was evaluated in rat lungs that underwent mechanical ventilation through a tracheostomy. There was a distribution difference in pro-inflammatory cytokine expression among lung areas. Cytokine expression was also different in lungs with different tidal volume ventilation. We confirmed a distribution difference in lung injury among lung areas, which gives ground for research on lung injury according to transpulmonary pressure.
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| Free Research Field |
急性肺傷害
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| Academic Significance and Societal Importance of the Research Achievements |
人工呼吸の設定を決める際に、どのような換気量が適しているか、呼気終末陽圧（positive end-expiratory pressure, PEEP）をいくつにしたら良いか、プラトー圧以外に何を指標にすべきかなど、未だコンセンサスが得られていない。近年driving pressureや経肺圧を指標に呼吸器設定することが提案されている。経肺圧も肺の部位によって異なるため、その部位ごとの値の違いを知ることが、今後の呼吸器戦略における重要な布石になると考えられる。
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