2022 Fiscal Year Final Research Report
functional significance of HDAC7 expression in glioblastoma focusing on the mitochondria function
| Project/Area Number |
20K09395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Kyushu University (2022)
Kagoshima University (2020-2021) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
比嘉 那優大 鹿児島大学, 鹿児島大学病院, 医員 (90792200)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | glioblastoma / HDAC7 / glycolysis |
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| Outline of Final Research Achievements |
HDAC7 plays an important role in acquisition of malignant feature of glioma, shuffling between nucleus and cytoplasm. We first speculate that HDAC7 localize in mitochondria, but the result is that HDAC7 does not localize in mitochondria, but in the other compartment of cytoplasm. Also, we have identified that HDAC7 binds with glycolysis pathway related proteins. Accordingly, we demonstrated that HDAC7 knockdown in U251 cell decrease the glucose intake. Therefore, our results suggest that HDAC7 functions in regulating glycolysis pathway in glioma cells and tissues.
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| Free Research Field |
脳腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
膠芽腫は依然難治性の疾患であり、有効な治療法が開発されていない。本研究成果は、HDAC７が細胞質の解糖系を制御することで、腫瘍の悪性化に関与していることを示唆するものである。近年は腫瘍細胞の代謝が治療標的として注目を浴びており、その機序としてHDACの関与が考えられるため、HDC7を標的にすることで膠芽腫の新たな治療戦略の確立に結びつつけられる可能性がある。
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