2022 Fiscal Year Final Research Report

Establishment of biomimetic vein wrapping to treat chronic nerve injury

Research Project

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Project/Area Number	20K09415
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56020:Orthopedics-related
Research Institution	Kitasato University
Principal Investigator	Inoue Gen 北里大学, 医学部, 准教授 (80594209)
Co-Investigator(Kenkyū-buntansha)	内田健太郎北里大学, 医学部, 講師 (50547578) 松下治岡山大学, 医歯薬学総合研究科, 教授 (00209537) 大鳥精司千葉大学, 大学院医学研究院, 教授 (40361430) 馬渕洋順天堂大学, 大学院医学研究科, 特任准教授 (50424172) 宮城正行北里大学, 医学部, 講師 (90627556)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	Vein Wrapping / バイオミメティクス / 絞扼性末梢神経傷害
Outline of Final Research Achievements	Autologous vein wrapping is used to treat recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, its use is restricted due to the inability to obtain sufficiently long veins for larger grafts. To mimic vein wrapping, we developed a high density collagen sheet (HCS) soaked with bFGF. In the bFGF/CS group, Hmox1 messenger RNA and HO-1 protein levels were significantly increased in the sciatic nerve compared with the control and PBS/HCS groups on PODs 1 and 5 and POD 1, respectively. The bFGF/HCS group showed decreased allodynia and HO-1 induction. Therefore, bFGF/HCS composite may be an alternative treatment strategy for compressive neuropathy and peripheral nerve trauma in clinical settings.
Free Research Field	整形外科学
Academic Significance and Societal Importance of the Research Achievements	重度末梢神経障害は、患者の肉体的精神的苦痛に加える。加えて、入院および通院治療の増加による医療費増加、社会復帰遅延による多大な経済損失に直結する。従って、重度末梢神経障害治療法の開発は急務である。本研究結果は新たな重度末梢神経障害治療法に繋がる社会的意義の大きい研究である。