2022 Fiscal Year Final Research Report
Establishment of biomimetic vein wrapping to treat chronic nerve injury
Project/Area Number |
20K09415
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56020:Orthopedics-related
|
Research Institution | Kitasato University |
Principal Investigator |
Inoue Gen 北里大学, 医学部, 准教授 (80594209)
|
Co-Investigator(Kenkyū-buntansha) |
内田 健太郎 北里大学, 医学部, 講師 (50547578)
松下 治 岡山大学, 医歯薬学総合研究科, 教授 (00209537)
大鳥 精司 千葉大学, 大学院医学研究院, 教授 (40361430)
馬渕 洋 順天堂大学, 大学院医学研究科, 特任准教授 (50424172)
宮城 正行 北里大学, 医学部, 講師 (90627556)
|
Project Period (FY) |
2020-04-01 – 2023-03-31
|
Keywords | Vein Wrapping / バイオミメティクス / 絞扼性末梢神経傷害 |
Outline of Final Research Achievements |
Autologous vein wrapping is used to treat recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, its use is restricted due to the inability to obtain sufficiently long veins for larger grafts. To mimic vein wrapping, we developed a high density collagen sheet (HCS) soaked with bFGF. In the bFGF/CS group, Hmox1 messenger RNA and HO-1 protein levels were significantly increased in the sciatic nerve compared with the control and PBS/HCS groups on PODs 1 and 5 and POD 1, respectively. The bFGF/HCS group showed decreased allodynia and HO-1 induction. Therefore, bFGF/HCS composite may be an alternative treatment strategy for compressive neuropathy and peripheral nerve trauma in clinical settings.
|
Free Research Field |
整形外科学
|
Academic Significance and Societal Importance of the Research Achievements |
重度末梢神経障害は、患者の肉体的精神的苦痛に加える。加えて、入院および通院治療の増加による医療費増加、社会復帰遅延による多大な経済損失に直結する。従って、重度末梢神経障害治療法の開発は急務である。本研究結果は新たな重度末梢神経障害治療法に繋がる社会的意義の大きい研究である。
|