2022 Fiscal Year Final Research Report
Analysis of action of neurotrophic factor precursor via glutamatergic signal transmission that is involved in voiding dysfunction after spinal cord injury
| Project/Area Number |
20K09575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 排尿障害 / 脊髄損傷 / 神経栄養因子 / 代謝型グルタミン酸 / 膀胱 / 外尿道括約筋 / マウス |
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| Outline of Final Research Achievements |
Chronically spinal cord injured mice present detrusor-sphincter dyssynergia. In the meantime, there are some silent periods that show synergic activity of the bladder and external urethral sphincter during the bladder contraction (i.e., decreased urethral resistance), which lead to urine evacuation. In addition, the present study revealed that p75NTR plays important role in the mechanism associated with synergic activity of the bladder and external urethral sphincter in the plastic change after spinal cord injury.
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| Free Research Field |
神経泌尿器科学
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| Academic Significance and Societal Importance of the Research Achievements |
慢性脊髄損傷は、排尿筋外尿道括約筋協調不全を惹起し、排尿障害を起こす。やがて腎機能不全を呈するようになり、時として生命を脅かす。膀胱内が異常な高圧状態になることを回避できるよう、膀胱収縮時には外尿道括約筋が弛緩し、尿道抵抗が減弱することが望ましい。
本研究では、脊髄損傷後に排尿筋外尿道括約筋協調不全を呈するメカニズムの一端を明らかにした。今回の研究成果が、将来的に、排尿筋外尿道括約筋協調不全を緩和し、膀胱と尿道の協調性のある活動へと導く治療法開発に役立つことが期待される。
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