2022 Fiscal Year Final Research Report
Verification of the safety and effectiveness of a test for predicting malignant transformation of endometriosis
| Project/Area Number |
20K09648
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
吉元 千陽 奈良県立医科大学, 医学部, 研究員 (00526725)
小林 浩 奈良県立医科大学, 医学部, 研究員 (40178330)
松原 翔 奈良県立医科大学, 医学部附属病院, 研究員 (20825236)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | 子宮内膜症 |
|---|
| Outline of Final Research Achievements |
The interactance method has made it possible to estimate iron and hemoglobin concentrations with higher sensitivity than the conventional reflectance method. A strong correlation was observed between the iron concentration measurement by the interactance method and the actual iron level in the cystic fluid (r=0.558, P<0.001) in the endometriosis group and the ovarian cancer group. The Phase 1 trial was completed on schedule and confirmed to be safe. Interaction method was used instead of reflected light for better accuracy. The near-infrared light irradiation device was built into the cover attached to the probe of transvaginal ultrasound. The iron concentration was successfully measured using the Unscrambler X hemoglobin concentration measurement analysis software by irradiating light from the tip of the probe and collecting information on the PC via the detector.
|
| Free Research Field |
子宮内膜症
|
| Academic Significance and Societal Importance of the Research Achievements |
超音波診断装置内蔵一体型の経腟光学プローブを設計試作することにより、どの機器にでも装着することができ、鉄濃度測定のために新規の超音波診断装置を購入しなくても測定可能である。本プローブを使用することにより隆起性病変が出現する前に癌化の過程を歩んでいる内膜症患者を予測することも可能となる。なお、内膜症からのがん化は比較的若年で発生するため、早期発見が急務である。経腟光学プローブは2015年に特許を取得しており、海外への展開も視野に入れることができると考えている。
|
