Development of a Novel Preventive Method for Cervical Cancer

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09654
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: University of Human Arts and Sciences (2023); Tokyo Medical University (2020-2022)
• Principal Investigator: Kumagai Katsuyoshi 人間総合科学大学, 人間科学部, 講師(移行) (20567911)
• Co-Investigator(Kenkyū-buntansha): 須藤 カツ子 東京医科大学, 医学部, 兼任講師 (50126091) ; 西 洋孝 東京医科大学, 医学部, 主任教授 (60307345) ; 高梨 正勝 東京医科大学, 医学部, 講師 (80312007) ; 原田 裕一郎 東京医科大学, 医学部, 助手 (80570168) ; 大野 慎一郎 東京医科大学, 医学部, 講師 (90513680)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: WAPL / CIN / MACROD1

Outline of Final Research Achievements

Currently, the number of cervical cancer patients and the mortality rate are increasing in our country, particularly among young people aged 20 to 40. Cervical cancer, when detected at the cervical intraepithelial neoplasia (CIN) stage, can be treated with relatively low invasiveness and good prognosis. However, if the disease progresses, surgical treatment carries significant risks. Since 2013, our country has actively refrained from the only preventive measure, which was vaccination against the human papillomavirus (HPV), the cause of cervical cancer. This study aims to develop an alternative preventive measure by applying molecules obtained from the analysis of a mouse model of cervical cancer precancerous lesions. The results of this research will aim to develop a groundbreaking preventive method to prevent the onset of cervical cancer in the young age group, which is most susceptible.

Free Research Field

産科婦人科

Academic Significance and Societal Importance of the Research Achievements

本研究は、前癌病変モデルマウスの解析から得られた分子を応用し、ワクチンに代わる新しい低侵襲性の子宮頸癌予防法を開発することを目指しており、この新規予防法の確立により、若年層における子宮頸癌の罹患率を低減し、女性の健康を守り、予防医療を促進するとともに、HPV感染やその予防策に関する認識を高めることに大きな学術的および社会的意義を有する。