Mechanism of DOHaD theory in preeclampsia: Significance of inflammasome mechanism

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09655
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: Shirasuna Koumei 東京農業大学, 農学部, 教授 (20552780)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 妊娠 / 免疫 / 炎症 / 次世代

Outline of Final Research Achievements

Changes of the maternal environment, such as preeclampsia, are associated with both the mother and child to fall into a serious condition with abnormalities. The DOHaD theory (Developmental Origins of Health and Disease theory) is attracting attention. To clarify this theory, we tried to investigate an analysis model using mice revealed that maternal conditions, such as hypertension, stress, and aging, not only induce inflammatory conditions in the mother itself, but also affect blood pressure and lipid metabolism after growth in the next generation.

Free Research Field

生殖免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、妊娠高血圧腎症等における自然炎症を中心とした炎症機構の解明の一助となると考える。また、妊娠高血圧腎症等の母体環境が子供の将来の疾患リスクにどのように関連するのかという「母体病態のDOHaD説」の理解につなげることができる。将来的に、母体の自然炎症をコントロールする介入手段により、妊娠高血圧腎症や子供の将来の疾患リスクの両面を対象とした新規治療方法の開発に繋がることが期待される。