Study for the central regulation of female reproductive endocrinology

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09671
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Shimane University
• Principal Investigator: Kanasaki Haruhiko 島根大学, 学術研究院医学・看護学系, 准教授 (10325053)
• Co-Investigator(Kenkyū-buntansha): 折出 亜希 島根大学, 学術研究院医学・看護学系, 講師 (00423278)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 視床下部 / キスペプチン / GnRH / インヒビン / アクチビン / フォリスタチン

Outline of Final Research Achievements

1）Activin, inhibin, and follistatin expressed in the brain participate in the E2-induced feedback control of the hypothalamic-pituitary-gonadal axis.2）Hyperandrogenemia affects KNDy neurons and changes their neuronal characteristics by increasing kisspeptin and NKB levels and decreasing DynA levels. These changes might cause dysfunction of the hypothalamic-pituitary-gonadal axis.3）AMH participates in hypothalamic-pituitary-gonadal axis control by stimulating GnRH expression. In addition, AMH might be a potent repressor of Kiss-1 gene expression induced by KP10.4）Kisspeptin and GnRH affected Kiss-1- and GnRH-expressing hypothalamic cells and modulated Kiss-1 and/or GnRH gene expression with a concomitant increase in c-Fos protein expression. A mutual- or self-regulatory system might be present in Kiss-1 and/or GnRH neurons in the hypothalamus.

Free Research Field

生殖内分泌

Academic Significance and Societal Importance of the Research Achievements

キスペプチンニューロンの制御機構の一端を解明できた。