2022 Fiscal Year Final Research Report
Integrative elucidation of myosin molecular transport function and warping regulatory mechanism in the inner ear stereocilia
| Project/Area Number |
20K09687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三輪 徹 大阪公立大学, 大学院医学研究科, 講師 (70535591)
岩城 光宏 国立研究開発法人理化学研究所, 生命機能科学研究センター, 客員研究員 (30432503)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | TRIOBP |
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| Outline of Final Research Achievements |
Since hair cell culture was unsuccessful in mice, the animal species was changed to guinea pigs. To generate TRIOBP-1 knockdown guinea pigs, we constructed an RNA interference system elastic body. We tried to introduce Cy3-labeled DNA springs provided by our collaborators into hair cells, but due to lack of funds for experiments, we were unable to carry out further experiments.
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| Free Research Field |
耳鼻咽喉科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、内耳だけに限定されない普遍的なミオシンの活性調節に新たな知見をもたらす可能性があった。
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