Prophylactic neck dissection for oral cancer based on liquid biopsy

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Osaka University
• Principal Investigator: Suzuki Motoyuki 大阪大学, 大学院医学系研究科, 助教 (50632329)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 舌癌 / リキッドバイオプシー

Outline of Final Research Achievements

DNA targeting sequencing was performed on 27 cases of tongue cancer in which DNA was extracted and fragmented from primary tumors and blood. 23 (85%) of the cases had target gene mutations. A significant correlation between Stage and ctDNA copy number was observed (p<0.001). A strong correlation was also observed between DOI of the primary tumor and ctDNA. There were three cases in which the mutation remained in the plasma around 1 week postoperatively, and two of them subsequently recurred. Furthermore, ctDNA at the time of recurrence was detected in all but one case.

Free Research Field

頭頚部癌

Academic Significance and Societal Importance of the Research Achievements

舌癌患者のリキッドバイオプシーによりターゲットとなる遺伝子変異は進行癌では検出可能であり、早期癌でも再発時には多くの症例で検出された。また、一部の症例では術後早期に潜在的再発を予測できた。今後有用なバイオマーカーとなり得ることが示唆された。