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2023 Fiscal Year Final Research Report

Investigation of Synkinesis in Facial Nerve Regeneration Therapy Using Basic Fibroblast Growth Factor

Research Project

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Project/Area Number 20K09714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionEhime University

Principal Investigator

Hiroyuki Yamada  愛媛大学, 医学系研究科, 准教授 (00403808)

Co-Investigator(Kenkyū-buntansha) 脇坂 浩之  愛媛県立医療技術大学, 保健科学部, 教授 (30304611)
木村 拓也  愛媛大学, 医学部附属病院, 専攻医 (40792502)
Project Period (FY) 2020-04-01 – 2024-03-31
Keywords顔面神経麻痺 / 病的共同運動 / 神経過誤支配 / 再生医療 / アブミ骨筋性耳鳴 / 二光子励起顕微鏡 / Misdirection
Outline of Final Research Achievements

In this study, we utilized a severe facial nerve paralysis model to demonstrate the occurrence of synkinesis during chewing movements on the affected side, as well as the emergence of synkinesis in Blink Reflex testing. Additionally, we successfully achieved the first objective evaluation of stapedial tinnitus in an animal model using a laser Doppler vibrometer. Quantitative assessment of misdirection was conducted through three-dimensional analysis using two-photon excitation microscopy. The results revealed an average Misdirection ratio of 90.5% and an average Double-labeled cell ratio of 16.45%. This study introduces novel analytical methods for fundamental research on the sequelae of facial nerve paralysis.

Free Research Field

耳科学

Academic Significance and Societal Importance of the Research Achievements

顔面神経は多くの表情筋を支配し複雑で様々な表情を作る。表情は非言語コミュニケーションの1つとされ円滑な社会的生活を営むために必要である。しかし、高度顔面神経麻痺に陥るとMisdirection が生じ、眼瞼を動かすと同時に口角が動き、自然な表情が作れなくなる。また顔面神経はアブミ骨筋も支配しているためMisdirectionにより食事や閉眼時にアブミ骨筋が収縮し耳鳴が生じる。上記のような後遺症のため患者の社会的生活が損われる。本研究は顔面神経麻痺の後遺症に対する基礎研究において新たな解析方法を示すことができた。これらの方法により今後、益々後遺症克服に向けた研究が推進さると考えられる。

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Published: 2025-01-30  

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