2022 Fiscal Year Final Research Report
Involvement of Neuromedin U in the pathogenesis of allergic rhinitis and analysis for innovative drug discovery.
| Project/Area Number |
20K09720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
花田 礼子 大分大学, 医学部, 教授 (00343707)
木村 徹 杏林大学, 医学部, 講師 (30433725)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Neuromedin-U / Neuromedin-U receptor-1 / Neuromedin-U receptor-2 / アレルギー性鼻炎の病態 / 獲得免疫 / 自然免疫 |
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| Outline of Final Research Achievements |
The involvement of Neuromedin U in the pathogenesis of allergic rhinitis (AR) was investigated using a mouse model of AR.
The results showed that Neuromedin-U (NMU) expression was confirmed by RT-PCR and protein localization (immunostaining) in the AR model mice, but contrary to expectations, NMU receptor 1,-2 and Mrgprx-1,-2, on which NMU may act, were also not detected . However, the expression of NMU receptor 1 in AR model mice during the sensitization phase by OVA suggested that about 1/3 of them are expressed.
In conclusion, NMU receptors are poorly expressed in the pathogenesis of type I allergy, in which acquired immunity is predominant.
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| Free Research Field |
上気道炎症の病態の解明
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| Academic Significance and Societal Importance of the Research Achievements |
アレルギー性鼻炎の発症の段階でのNMU rceptor-1の発現が, 約１/3の割合で示唆された. NMUは, ILC2を介した自然免疫系の関与による病態での発現が示唆されている. 従って, I型アレルギーの病態であるアレルギー性鼻炎の発症には, 獲得免疫が主であり, 自然免疫系の関与は乏しいことが示唆された. 自然免疫系の関与が大きいと考えられている好酸球性副鼻腔炎の病態での発現が期待される.
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