2022 Fiscal Year Final Research Report
Assessment of excised human larynx in N-vinyl-2-pyrrolidone embalmed cadaver as an experimental phonation model.
| Project/Area Number |
20K09737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 喉頭 / 声帯 / 音声 / モデル / 声帯振動 / 運動生理学 / 解剖 / 形態 |
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| Outline of Final Research Achievements |
Human vocal folds vibrate with high frequency to reach 100-200 Hz during conversation to have an important role for daily communication. There had been no experimental phonation model using human tissue to assess the mechanism of vocal fold vibration. In this study, we tried to establish a novel model to assess the motion physiology of vocal folds using excised larynx from N-vinyl-2-pyrrolidone (NVP) embalmed cadaver. High-speed digital imaging visualized regular vocal fold vibration with vibration amplitude similar to living human in the experimental phonation model. Furthermore, our new model successfully produced voiced sounds with frequency similar to living human. Additionally, we confirmed that the vocal parameters were reproducible 6 months after first experiment. We have published our results obtained from this study in a journal (Anat Sci Intl.).
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| Free Research Field |
音声喉頭科学
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| Academic Significance and Societal Importance of the Research Achievements |
学術的には、これまで動物からの摘出喉頭や、再現性の無いヒト新鮮（凍結）cadaverを用いていた音声再生実験を、再現性のあるヒトモデルで行う事が可能となったことで、ヒトの発声メカニズムを詳細に解析するための礎を築くことができたと。今後様々な音声改善手術のシミュレーションや、正確に音声を変化させる術式の確率への貢献が期待できる。
社会的には、コミュニケーションツールとしての「声」について研究が進むことで、音声障害を有する人々の、社会活動の量や質の向上に貢献できると考えている。一例として超高齢社会を迎えた日本では、加齢変化による音声障害患者は増加の一途を辿っており、本研究の成果を早急に活かしたい。
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