Identification of Prognostic factor and Therapeutic target of Salivary Duct Carcinoma by Multi institutional study

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Tokai University
• Principal Investigator: Okami Kenji 東海大学, 医学部, 教授 (90223734)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: Salivary Duct Carcinoma / 予後因子 / リンパ節転移 / 節外浸潤

Outline of Final Research Achievements

Basic and clinical research of the prognostica factor and the exploration of the new molecular target for the salivary duct carcinoma (SDC) were investigated. Surgically resected pathology specimens from multicenter cases were collected and analyzed for vascular invasion and extranodal involvement of metastatic lymph nodes by HE staining and immunohistochemical analysis. Pathological and clinical prognostic factors were analyzed by identifying associations between clinicopathological factors and survival. Molecular prognostic factors were also analyzed in relation to clinicopathological factors and the accumulation of findings in a large number of SDCs, providing many insights into the pathogenesis of SDC and its treatment target.

Free Research Field

頭頸部癌

Academic Significance and Societal Importance of the Research Achievements

単施設での研究では希少がんである本疾患の病態を明らかにすることは困難であったが，多施設の標本と臨床データをもとに行った研究は非常に意義深い．予後不良なSalvary duct carcinomaに対する治療，予後因子，新規治療分子を確立することで，この疾患の治療について新しい知見を得ることができた．新規治療標的を明らかにすることで，新しい治療の臨床応用への橋渡しができた．