2023 Fiscal Year Final Research Report
Elucidation of the Mechanism for Acquiring Oxidative Stress Resistance during the Skin Wound Healing Process.
| Project/Area Number |
20K09856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
久保 盾貴 大阪大学, 大学院医学系研究科, 教授 (00362707)
藤原 敏宏 兵庫医科大学, 医学部, 講師 (00423179)
西本 聡 兵庫医科大学, 医学部, 教授 (30281124)
石瀬 久子 兵庫医科大学, 医学部, 講師 (30567194)
垣淵 正男 兵庫医科大学, 医学部, 教授 (50252664)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 創傷治癒 / TRPC3 |
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| Outline of Final Research Achievements |
In this study, we focused on TRPC3, a type of Ca2+ channel, as a mechanism responding to oxidative stress. The goal was to elucidate how skin fibroblasts acquire oxidative stress resistance through TRPC3.
However, since we were unable to successfully create TRPC3 knockout fibroblasts using the CRISPR Cas9 system, we conducted an investigation into the interaction between fibroblasts and epithelial cells during mechanical stimulation based on preliminary studies related to TRPC3.
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| Free Research Field |
形成外科
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| Academic Significance and Societal Importance of the Research Achievements |
創傷治癒研究は、外傷後の治癒過程を理解し改善するための重要な分野であり、手術後の回復期間の短縮や糖尿病患者など創傷治癒が困難な慢性創傷の治療改善につながり、社会的な負担の軽減にも繋がる。本研究において創傷治癒過程においてTRPCイオンチャネルが重要な役割を果たしている可能性が示唆された。
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