Functional analysis of B7-like protein ILDR2

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Hiroshima University
• Principal Investigator: Kawano Yohei 広島大学, 医系科学研究科(医), 准教授 (20401383)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: B7ファミリー

Outline of Final Research Achievements

The aim of this study was to elucidate the physiological significance of a novel B7-like molecule, ILDR2 by investigating the expression pattern and function in the immune system. RT-PCR analysis for the transmembrane form of ILDR2 in the immune system suggested its expression in antigen-presenting cells (B cells, dendritic cells), as well as myeloid cells. Attempts were made to acquire mouse ILDR2-specific monoclonal antibodies for functional studies. Although the desired monoclonal antibody were not obtained during the course of this study, future efforts are expected for acquiring the monoclonal antibody.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

現在、免疫制御の破綻が感染症、自己免疫疾患、アレルギーやがんなどのさまざまな免疫疾患につながると考えられている。現在のがん免疫療法における劇的な治療効果からもわかるように、PD-L1を代表とするB7ファミリー分子は免疫制御において重要な役割を担っている。B7様分子であるILDR2も同様な機能を持つことがわかれば、本研究で行ってきた抗体の開発過程は今後ILDR2を標的とした抗体医薬開発における重要な知見となる。