Mechanisms of proliferation, invasion, and distant metastasis of malignant melanoma regulated by the amino acid sensor .

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09924
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Matsuo Kou 九州歯科大学, 歯学部, 教授 (70238971)
• Co-Investigator(Kenkyū-buntansha): 古株 彰一郎 九州歯科大学, 歯学部, 教授 (30448899) ; 矢田 直美 九州歯科大学, 歯学部, 准教授 (60468022) ; 永野 健一 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60834348)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 悪性黒色腫

Outline of Final Research Achievements

Malignant melanoma is a malignant tumor that develops on the skin and mucous membranes. Since plectin is highly expressed in patients with malignant melanoma, plectin may be related to the pathogenesis of malignant melanoma. In this study, we investigated the function of plectin in the behavior of malignant melanoma. plectin-deficient malignant melanoma cells were generated using the CRISPR/Cas9 system. The adhesive ability to fibronectin was also decreased. These results suggest that plectin regulates the growth and adhesion of malignant melanoma cells.

Free Research Field

口腔病理学

Academic Significance and Societal Importance of the Research Achievements

悪性黒色腫は非常に悪性度の高い悪性腫瘍であるが，免疫チェックポイント阻害剤の出現により，治療成績が著しく向上してきた．しかしながら，さまざまな臓器に対して免疫関連有害事象をもたらすことも明らかとなってきた．そのため，悪性黒色腫の病態を理解し新たな治療法を確立する必要性は依然として残っており本研究成果はそれらの解決のための一助となる可能性がある．