Development of antibiotics specific for periodontopathogens using inhibitors of a metabolic protein

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09930
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Aichi Gakuin University
• Principal Investigator: Yoshida Yasuo 愛知学院大学, 歯学部, 准教授 (10315096)
• Co-Investigator(Kenkyū-buntansha): 加藤 悦子 東洋大学, 食環境科学部, 教授 (00355752)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 歯周病 / 歯科 / 抗菌薬

Outline of Final Research Achievements

With the support of the drug discovery and other advanced technology support platform (BIND) and the Faculty of Food and Environmental Sciences, Toyo University, we focused on the enzymes essential for the growth of the periodontal pathogen Porphyromonas gingivalis, and investigated two types of enzyme-inhibiting compounds. A library (company and fluoride libraries) was used to obtain candidate compounds. The inhibitory effect on the growth of P. gingivalis and oral streptococcus Streptococcus gordonii was examined for multiple enzyme inhibitory compounds. In addition, as a result of biochemical studies using the purified enzyme, one candidate compound suitable as a candidate compound was obtained from a corporate library. In addition, several low-molecular-weight candidate compounds were obtained from the fluoride library. We believe that these results will greatly contribute to the development of periodontal pathogen-specific drugs.

Free Research Field

歯科

Academic Significance and Societal Importance of the Research Achievements

歯科内科という言葉が使用されて久しい。歯の切削と充填、抜歯や補綴などを行わない内科的治療は理想的であるが、検査法の確立と治療薬の開発とが不可欠である。一般開業医院においてもリアルタイムPCR法を用いた歯周病細菌の検査法が可能になり、診断法は開発されてきたが、歯周病細菌に特異的に作用する抗菌薬は皆無である。本研究では、歯周病原細菌を不活化する薬物を開発し、歯周病の新規予防法や治療法を提起する。