2022 Fiscal Year Final Research Report
Elucidation of bone formation mechanism of sustained-release zinc titanium and dental pulp stem cells and their application to jaw bone reconstruction
| Project/Area Number |
20K10089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 修 山形大学, 大学院理工学研究科, 教授 (00230540)
福田 雅幸 秋田大学, 医学部附属病院, 准教授 (20272049)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 顎骨再建 / 骨芽細胞 / 幹細胞 / 再生医学 / 分子生物学 |
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| Outline of Final Research Achievements |
Jawbone and occlusal reconstruction using dental implants are performed to address extensive jaw defects caused by tumors in the oral and maxillofacial region. Our previous reports have shown that these treatments can restore the function and quality of life of patients with jaw defects.
However, autogenous bone grafting for jawbone reconstruction has several issues, such as the limited amount of available bone and donor site invasion. Consequently, there is a growing need for minimally invasive jawbone reconstruction approaches that utilize regenerative medicine. The aims of this study are to establish a jawbone reconstruction method using zinc-modified titanium mesh sheets and dental pulp stem cells.
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| Free Research Field |
口腔外科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の遂行により、低侵襲かつ安全性を有した顎骨再建法の構築に貢献できると考えられる。さらに、現在までに行ってきた予備的研究では早期の骨芽細胞分化が確認されており臨床応用が可能となれば、治療期間の短縮により患者の身体的・経済的負担の改善にも寄与できると考えられる。
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