2022 Fiscal Year Final Research Report
Role of cytoskeletal regulator Plectin in growth, invasion, and metastasis of malignant melanoma.
| Project/Area Number |
20K10185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松原 琢磨 九州歯科大学, 歯学部, 准教授 (00423137)
矢田 直美 九州歯科大学, 歯学部, 准教授 (60468022)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 悪性黒色腫 |
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| Outline of Final Research Achievements |
Recently, we have identified plectin as a new factor that regulates Src activity. In this study, we investigated the function of plectin in the cell behavior of malignant melanoma. When nude mice were inoculated with plectin knockout cells, the density of tumor cells was lower than that of wild-type cells, and the interstitial spaces between cells were wider and sparser. Adhesion to fibronectin was also decreased. Furthermore, the proliferative ability of the knockout cells was evaluated, and the increase in cell number over time was reduced. plectin regulates the growth and adhesion of malignant melanoma via the oncogene Src signaling.
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| Free Research Field |
口腔外科学
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| Academic Significance and Societal Importance of the Research Achievements |
口腔領域に生じる悪性黒色腫は皮膚に発生した悪性黒色腫と比較すると予後不良であるにも関わらず，発症頻度が低いために研究は進んでいない．また，近年開発された新しい抗がん剤ruthenium pyridinecarbothioamideはplectinを標的とするが，その詳しい作用機序などはわかっていなかった．本研究はこれらの一助となることが期待される．
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