2023 Fiscal Year Final Research Report
The Mechanism of Intramuscular Tendon Development in Masticatory Muscle Tendon-Aponeurosis Hyperplasia
| Project/Area Number |
20K10191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 筋内腱 / 発生 / マウス / 咀嚼筋腱腱膜過形成症 |
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| Outline of Final Research Achievements |
In the masticatory muscles, numerous ‘intramuscular tendons’ exist within the muscle itself, distinct from tendons outside the muscle, such as the Achilles tendon. Recently, a novel condition called ‘masticatory muscle tendon-aponeurosis hyperplasia’ has gained attention. The main pathology of this condition involves excessive formation of tendons within skeletal muscles. To elucidate its etiology, it is essential to understand the developmental mechanism of ‘intramuscular tendons’ at the tendon-bone interface (enthesis). Our study revealed that Sox9, crucial for enthesis formation, exhibits high expression only during early fetal development and subsequently downregulates. Thus, the developmental process of ‘intramuscular tendon’ enthesis differs from that of typical entheses.
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| Free Research Field |
筋-腱-骨複合体(運動器)
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は咀嚼筋腱・腱膜過形成症の新規治療法へ向けた基礎研究であり，その第一歩として，筋内腱の腱-骨接合部の発生を検索した．その結果，アキレス腱などに代表される一般的な腱-骨接合部とは，その発生機序が異なることが明らかとなった．すなわち筋内腱には独自の発生パターンが存在し，この発生機序の全容解明が咀嚼筋腱・腱膜過形成症の新規治療法への第一歩になるとことを確信した．世界的に見て，腱研究はアキレス腱のような筋外腱のみが注目されており，我々の注目している筋内腱を独自ルートで追い求める意義を感じた．
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