2023 Fiscal Year Final Research Report
Establishment of a New School Urinalysis System using Urine Protein Creatinine Ratio
Project/Area Number |
20K10344
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 58010:Medical management and medical sociology-related
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | 学校検尿 / 尿蛋白クレアチニン比 / 尿β2ミクログロブリン / 先天性腎尿路異常 |
Outline of Final Research Achievements |
Early detection and early treatment are important in congenital anomalies of the kidney and urinary tract (CAKUT), and it is known that an increase in urinary β2-microglobulin (BMG) levels is observed early in the disease, making it an essential screening item during detailed examinations of school urine screening. In this study, we investigated the detection of children with high urinary β2-microglobulin levels using residual samples from actual school urine screening, with the cooperation of the Shiga Prefectural Board of Education. As a result, it was found that the current school urine screening system, which detects urinary proteins, is not sensitive enough to detect cases of elevated urinary β2-microglobulin levels, and that cases of elevated urinary β2-microglobulin levels are not being properly detected at the secondary school urine test as screening process. These findings suggest that many children with CAKUT may be overlooked at the current school urine screening.
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Free Research Field |
小児腎臓病学
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Academic Significance and Societal Importance of the Research Achievements |
尿蛋白検出を追求した現行の学校検尿システムでは先天性腎尿路異常で高値となることが多い尿BMGが上昇している児童生徒を検出するには感度が極めて低く、かつ3次精密検診に至る前のスクリーニングである2次検尿の段階で尿BMG上昇例が適切に検出されていないことが明らかである。先天性腎尿路異常は小児腎不全の最多原因であるためスクリーニング段階である1次/2次検尿で尿β2MGの上昇例を検出できるよう、安価でスクリーニングの意義が高い新たな検査学校検尿の検査手法を開発する必要がある。
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