Association of drug-resistant bacteria between human and vegetable or wild deer based on a One Health approach

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K10433
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Nara Medical University
• Principal Investigator: Nakano Akiyo 奈良県立医科大学, 医学部, 講師 (10707441)
• Co-Investigator(Kenkyū-buntansha): 矢野 寿一 奈良県立医科大学, 医学部, 教授 (20374944) ; 中野 竜一 奈良県立医科大学, 医学部, 准教授 (80433712)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 薬剤耐性菌 / 腸内細菌科 / 野菜 / 野生動物

Outline of Final Research Achievements

The purpose of this study was to clarify the prevalence of drug-resistant bacteria and relationship between human and vegetable or wild animal based on a One Health approach. Gram-negative bacteria resistant to 3rd-generation cephalosporin (3GC) were isolated from vegetables and wild deer in different habitats. Most of　these resistant bacteria had CTX-M β-lactamase genes. Prevalence of wild deer differed by habiting regions. Genomic types also differed from habiting regions and from types isolated from humans. This study was suggested that 3GC resistance bacteria from wild deer have a region-specific genome type and were not clearly associated between human and wild deer.

Free Research Field

微生物感染症

Academic Significance and Societal Importance of the Research Achievements

ワンヘルスアプローチに基づきヒトへの伝達経路として考えられる野菜と野生動物における薬剤耐性菌の分布状況を明らかにした。さらに野生鹿において薬剤耐性大腸菌を分離したがそのタイプはヒト由来大腸菌と異なることを明らかにした。餌やりなどでヒトとの交流が盛んな観光地で生息する野生鹿でさえ、ヒトとは異なるタイプの耐性菌を保有しており、ヒトと野生動物の薬剤耐性菌の関連性は低いことが示唆された。これは今後の観光地における感染対策を講じる上でも重要な指標となる。