Study on the protective factors for total mortality among HTLV-I carriers

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K10506
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Kagoshima University
• Principal Investigator: Takezaki Toshiro 鹿児島大学, 鹿児島大学病院, 特任教授 (50227013)
• Co-Investigator(Kenkyū-buntansha): 指宿 りえ 鹿児島大学, 医歯学域医学系, 助教 (90747015)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: HTLV-I / 全死亡リスク / コーホート研究 / ブロッコリー摂取 / 炎症 / 遺伝子多型

Outline of Final Research Achievements

This study was aimed to clarify protective factors for increased risk of all-cause mortality among HTLV-I carriers in cohort studies. The participants were 7,105 men and women, and an HTLV-I positivity rate of 6.5%. The hazard ratio for all-cause death with HTLV-I was 1.10 (0.75-1.61), which was not increased. On the other hand, the hazard ratio was 0.90 (0.57-1.41) in those with high broccoli intake and 2.39 (1.18-4.84) in those with low broccoli intake, and the interaction was also significant. There was no association with other environmental factors or host factors. The change in the risk of all-cause mortality associated with broccoli intake may be due to random error, but it is also suggested that the intake of anti-inflammatory foods may be associated with the risk of all-cause mortality for HTLV-I positivity.

Free Research Field

社会医学

Academic Significance and Societal Importance of the Research Achievements

HTLV-Iキャリアで報告されている全死亡リスクの上昇には、HTLV-I感染に伴う炎症が関与している可能性がある。本研究では、抗酸化作用や抗炎症作用を有するブロッコリーの摂取がHTLV-Iに伴う死亡リスクに影響を与えている可能性が始めて観察されたところに学術的意義がある。抗酸化作用や抗炎症作用を有する野菜摂取がHTLV-Iに伴う死亡リスク軽減に有用である可能性があり、予防に有用な知見が示された点で社会的意義がある。