2023 Fiscal Year Final Research Report
Genetic polymorphism in alcohol-metabolizing enzymes for reducing excessive drinking among Japanese college students and young adults: An open-label randomized controlled trial
| Project/Area Number |
20K10779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58060:Clinical nursing-related
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| Research Institution | Gunma Prefectural College of Health Sciences (2023)
University of Tsukuba (2020, 2022) |
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Principal Investigator |
Owaki Yukiko 群馬県立県民健康科学大学, 看護学部, 准教授 (30765392)
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| Co-Investigator(Kenkyū-buntansha) |
吉本 尚 筑波大学, 医学医療系, 准教授 (80608935)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 過剰な飲酒 / アルコール代謝酵素 / 遺伝子多型 / 簡易介入 / 行動変容ステージ / 大学生 / 若年成人 / ランダム化比較試験 |
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| Outline of Final Research Achievements |
This open-label, randomized controlled trial examined the effects of a brief intervention on college students and faculty aged 20-30. Information on five categories of alcohol-metabolizing enzyme (ALDH2 and ADH1B) combinations was collected. Participants (n=196) with an average alcohol intake of 40 g/day for men and 20 g/day or more for women were divided into intervention (n=100) and control groups (n=96). Four participants withdrew consent. The intervention group received their genetic test results by mail, followed by a face-to-face or online intervention tailored to their results. The intervention’s effectiveness was confirmed by reductions in alcohol intake and mean AUDIT-C scores on the screening test done 6 months later. Moreover, the intervention group showed an increase in the proportion of participants who transitioned from the "pre-contemplation" stage to "contemplation" or "action" on a model of behavioral change.
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| Free Research Field |
Nursing, Mental Health, Public Health
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は，飲酒と関連する個別的・客観的な遺伝的体質の情報を提供することにより，若年成人の過度の飲酒行動を予防する効果的な手法の可能性を検証した点で学術的な意義があり，公衆衛生にも有益である．この介入方法は，大学生や職場の若年成人の他の成人年齢層においても有効である可能性があり，今後も検証を継続する意義があると考えられる．
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