2022 Fiscal Year Final Research Report
Relationship between nutritional status and mastication after upper gastrointestinal surgery
| Project/Area Number |
20K11163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮尾 晋太朗 奈良県立医科大学, 医学部附属病院, 研究員 (00833708)
切畑屋 友希 奈良県立医科大学, 医学部附属病院, 研究員 (20865282)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 咀嚼力 / 術後栄養障害 / 口腔・嚥下機能 |
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| Outline of Final Research Achievements |
e investigated the relationship between the nutritional status of upper gastrointestinal tract surgery and the decline in oral swallowing function and nutritional status.
We created a model of decreased masticatory function using Wister rats with extracted teeth, and evaluated its gastric and intestinal motility function in comparison with that of healthy rats. However, the results were not as expected because the decrease in chewing ability was less than expected even after tooth extraction in rats, and nutritional disorders were less.
An experiment using chewing gum was planned, but this experiment was delayed because of the risk of spreading infection and the difficulty of measuring mastication ability in person due to the COVID-19. The repeated salivary swallow test was found to be strongly associated with postoperative complications and postoperative malnutrition after esophageal cancer surgery, and the results were presented at an academic conference.
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| Free Research Field |
上部消化管外科
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| Academic Significance and Societal Importance of the Research Achievements |
口腔嚥下機能とくに反復唾液嚥下テストと術後合併症および患者の栄養状態は密接に関連することが判明した．この測定は簡便にベッドサイドで施行することができるため，非常に有用な検査である．反復唾液嚥下テストが低下している患者に対しては術後の低栄養を防ぐため，術直後から長期にわたる嚥下リハビリの継続の必要性が示唆された．これらの知見により周術期管理が見直されることが想定されるため，非常に重要なことがわかったと考えられた．
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