2022 Fiscal Year Final Research Report
Analysis of muscle injury recovery promotion mechanism by ultrasonic stimulation using muscle injury model mice
| Project/Area Number |
20K11294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Tokoha University |
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Principal Investigator |
Agata Nobuhide 常葉大学, 保健医療学部, 准教授 (00549313)
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| Co-Investigator(Kenkyū-buntansha) |
伊東 佑太 名古屋学院大学, リハビリテーション学部, 准教授 (30454383)
清島 大資 東海大学, 医学部, 講師 (80756370)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 筋損傷 / マウス / 超音波刺激 |
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| Outline of Final Research Achievements |
Ultrasound is expected to be a stimulus that promotes recovery from muscle injury, but the scientific evidence is lacking. It has been clarified that muscle regeneration is caused by complex crosstalk among immune cells, satellite cells, and muscle cells, but the relationship with ultrasound stimulation is unknown. Therefore, in this study, we created a muscle injury model in mice and verified the effects of ultrasonic stimulation on muscle satellite cells, muscle cells, and macrophages, and investigated the mechanism of promoting recovery from muscle injury. As a result, we were able to create a muscle injury model in mice. Furthermore, we found that ultrasound stimulation promoted the proliferation of muscle satellite cells.
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| Free Research Field |
理学療法学
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| Academic Significance and Societal Importance of the Research Achievements |
筋損傷に対する理学療法は経験則に基づいて行われていることが多い．一方，超音波治療は一般的な物理療法機器であり，多くの病院などに設置されている．よって，超音波刺激による筋損傷からの回復の分子メカニズムが明らかになれば，科学的根拠に基づく効果的・効率的な筋損傷に対する治療が，多くの医療現場で提供することができるようになると考える．本研究は，マウスの筋損傷モデルを作製し，それを用いて超音波刺激による筋損傷から回復促進の分子メカニズムを解明する試みであった．よって本研究の成果は，筋損傷に対する科学的根拠に基づく理学療法の開発に繋がると考える．
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