2022 Fiscal Year Final Research Report
Effect of rehabilitation on the white matter and evaluation of motor function using 3D motor analysis in the rat model of cerebral infarction.
| Project/Area Number |
20K11295
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 59010:Rehabilitation science-related
|
|---|
| Research Institution | Tokoha University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森下 紗帆 常葉大学, 健康プロデュース学部, 助教 (30614010)
梅村 和夫 浜松医科大学, 医学部, 教授 (40232912)
吉川 輝 昭和大学, 医学部, 助教 (90737355)
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | 三次元動作分析 / 脳梗塞 |
|---|
| Outline of Final Research Achievements |
In order to investigate the effects of neurological rehabilitation using the rodent model of cerebral infarction, it is important to clarify the relationship between motor dysfunction and structural changes in the brain. In this study, we improved the system of three dimensional (3D) kinematic analysis with a high-speed digital camera for evaluation of rodent behavior. And, also we performed 3D kinematic analysis of the rat model of cerebral infarction that was induced by photochemical induced thrombosis (PIT). This analysis enabled us to detect certain motor dysfunction on the affected side. In addition, Nano-suit method which enables both high-resolution and macro-imaging of fixed specimens gave preliminary results showing differences in the structure of myelin within the white matter of the brain between sham- and PIT-operated rats.
|
| Free Research Field |
リハビリテーション医学
|
| Academic Significance and Societal Importance of the Research Achievements |
脳梗塞は発症後に後遺症を残し日常生活に支障をきたす代表的な疾患であり, 機能改善を促すリハビリは必要不可欠であるがその機序について不明なことが多く, 実験的動物モデルで調べている.高速三次元動作分析法の改善によりモデル動物の障害の回復度合いを, より詳細に捉えられるようになることで, 本疾患ばかりでなくリハビリの効能を評価できるようになることへの応用でき, ミエリン鞘などの脳内における組織構造の違いとの関係性を明らかにする礎となる知見と考えられる.
|
