Exercise therapy against the development of diabetic kidney disease

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11394
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Dokkyo Medical University
• Principal Investigator: Hara Kenji 獨協医科大学, 医学部, 准教授 (50438701)
• Co-Investigator(Kenkyū-buntansha): 橋本 貢士 獨協医科大学, 医学部, 教授 (30396642)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 運動療法 / 糖尿病 / QOL / 高齢者

Outline of Final Research Achievements

In the exercise therapy, one of the basic treatments for type 2 diabetes patients, 1) a resistance exercise program that can be easily started and continued unsupervised (at home, alone) was developed, and a manual and instructional video DVD were produced; 2) the effects of the unsupervised aerobic exercise program were examined, and the results showed significant improvements in HbA1c, systolic blood pressure, and BMI in elderly type 2 diabetic patients significantly improved HbA1c level, systolic blood pressure, and BMI after 12 weeks. When HRQOL (health-related quality of life) was also evaluated, all 8 items improved, 4 of which showed significant improvement. Although this intervention study did not achieve clear improvement in renal function, it did confirm the effectiveness of continued exercise therapy in improving HRQOL. Future studies will examine the effects of the unmonitored resistance training program, which is expected to include the effect of dialysis prophylaxis.

Free Research Field

糖尿病運動療法

Academic Significance and Societal Importance of the Research Achievements

超高齢化を迎える本邦において、サルコペニアやフレイル対策として運動療法の重要性は論を待たない。また運動療法は糖尿病治療における基本のひとつでありながら、その開始や継続が困難とされている。本研究では、低強度の運動実践であっても血糖降下、減量、収縮期血圧の低下を得ることができ、更にHRQOLも改善させた。運動療法の効果として「生活の質の向上を得ることができる」治療法ともいえる結果であり、運動療法を開始継続させる上で本研究の意義は高いものと考えられる。今後は腎機能低下患者において、作成した非監視下でのレジスタンストレーニングプログラムの効果を検証する予定であり、透析予防効果も含め期待される。