2023 Fiscal Year Final Research Report
Development and application of a new method for measuring and evaluating arterial vascular endothelial function
| Project/Area Number |
20K11467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59030:Physical education, and physical and health education-related
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| Research Institution | Hiroshima International University (2021-2023)
Prefectural University of Hiroshima (2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山岡 雅子 (遠藤雅子) 県立広島大学, 人間文化学部, 教授 (30336911)
鍛島 秀明 県立広島大学, 人間文化学部, 准教授 (40714746)
林 直亨 早稲田大学, スポーツ科学学術院, 教授 (80273720)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 運動 / 血管内皮機能 / 運動トレーニング / 測定評価方法 |
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| Outline of Final Research Achievements |
It is important to evaluate the functionality of the endothelium, since a deterioration of vascular endothelial function is a precursor to the onset of atherosclerosis. Currently, a common method for evaluating endothelial function is to apply an impulse-like shear stress (SS) stimulus to the vascular endothelium using the phenomenon of reactive hyperemia and measure the degree of the vasodilation. This method has a major substantial problem in that SS stimulation cannot be controlled identically between and within individuals at each measurement trial. In this study, we solved this problem and proposed a novel and comprehensive method alternatively. Specifically, this method involves the development of a technique that applies constant SS stimulation in multiple stages and an evaluation strategy that fits the measurement results to a sigmoid curve. The validity and its applicability (using the exercise training experiment) of the method were verified.
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| Free Research Field |
運動生理学
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| Academic Significance and Societal Importance of the Research Achievements |
動脈硬化発症の第一歩は，血管内皮細胞の「軽微な」機能低下から生じる。従って，動脈血管の内皮機能を正常，あるいはよりよい状態に保つことは，心血管性疾患の発症や進展を抑える上で極めて重要で，その機能を簡便に測定，評価する必要がある。現在，ヒト血管内皮機能性の評価にはFlow Mediated Dilation（FMD）法が広く適用されてきているが，いくつかの課題が残されている。そこで本研究では，現行法の課題を解決した新たな測定評価手法を開発し，その妥当性や応用性を検討したところ，極めて良好な結果を得た。本研究で提案された新たな手法が普及し，より広く利用されることが期待される。
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