Research on usefulness of serum fatty acid concentrations as markers of fat accumulation in viscera, liver, and pericardia.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11505
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: University of Tsukuba
• Principal Investigator: Yatoh Shigeru 筑波大学, 医学医療系, 教授 (50451703)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 内臓脂肪 / 生活習慣病 / 2型糖尿病 / 血中脂肪酸濃度 / パルミトレイン酸 / パルミチン酸

Outline of Final Research Achievements

Study participants were 25. Age was 57+/-11(mean+/-SD). They included 17 of fatty liver (more than moderate was 16), 11 of non-alcoholic steatohepatitis, 18 of type 2 diabetes mellitus, 17 of dyslipidemia, and 13 of hypertension. Body mass index (BMI) was 29.1+/-6.1 kg/m2. Observation period was 6.4+/-1.2 months.
Change of visceral fat before and after observation period, significantly correlated palmitoleic acid (C16:1(n-7))/palmitic acid (C16:0) ratio.

Free Research Field

代謝内分泌学

Academic Significance and Societal Importance of the Research Achievements

内臓脂肪量の増加は様々な生活習慣病の悪化に関与し、通常腹部のCT画像を用いて計測されるが、放射線被曝を伴うため頻回に測定することは困難である。今回、血中パルミトレイン酸/パルミチン酸濃度比の変化が内臓脂肪量の変化と相関することが明らかになったため、この指標を用いて内臓脂肪の減少を目指した診療が可能となる。