Roles of tryptophan-sensing receptor GPR142 in immune regulation

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Iwakura Hiroshi 和歌山県立医科大学, 薬学部, 教授 (20378615)
• Co-Investigator(Kenkyū-buntansha): 上田 陽子 和歌山県立医科大学, 医学部, 助教 (80794809)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: GPR142

Outline of Final Research Achievements

We found that GPR142 expression levels in the stomach of morbidly obese patients were correlated with those of proinflammatory cytokines. Moreover, GPR142 expression level was increased with addition of proinflammatory cytokines to the medium in ghrelin-producing cell line, MGN3-1 cells. However, the degree of inflammation in the three different mice models, namely colitis with DDS, gastritis with ethanol, and LPS-induced inflammation models, were not affected by deletion of GPR142 gene.

Free Research Field

内分泌代謝学

Academic Significance and Societal Importance of the Research Achievements

これまでの検討により、トリプトファン感知受容体GPR142の発現レベルが、炎症性サイトカインによって調節を受けることが明らかとなった。トリプトファンはそのキヌレニン系路による代謝物が免疫調節作用を持つことが知られており、トリプトファン濃度の感知が炎症調節に関わる可能性が考えられる。今回の炎症モデルでは、GPR142シグナルが炎症に与える影響は確認されなかったが、炎症によってGPR142発現が調節を受ける意義の解明が期待される。