Association of cerebral oxygenation and cognitive function with nutritional status in chronic kidney disease patients without dialysis therapy

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K11534
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Jichi Medical University
• Principal Investigator: Ookawara Susumu 自治医科大学, 医学部, 教授 (50724522)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 栄養指導 / 慢性腎臓病 / 認知機能 / Body mass index / 脳内局所酸素飽和度

Outline of Final Research Achievements

To summarize the study on "The relationship between cerebral oxygen dynamics, cognitive function, and nutritional parameters in patients with chronic kidney disease," it was revealed that in patients with chronic kidney disease not undergoing dialysis therapy, changes in the Mini-Mental State Examination score, an assessment scale for cognitive function, showed a significant positive correlation with changes in BMI and changes in regional cerebral oxygen saturation, respectively. Therefore, these results would be considered that maintaining cerebral oxygen dynamics and physical condition through nutritional intervention leads to the maintenance and improvement of cognitive function in patients with chronic kidney disease not undergoing dialysis therapy.

Free Research Field

栄養学　腎臓病学

Academic Significance and Societal Importance of the Research Achievements

本邦における慢性腎臓病症例は増加の一途をたどり、腎機能障害自体が認知機能障害の危険因子となるため、日常臨床では慢性腎臓病に認知機能障害を合併する症例の増加が問題となっている。本研究により、慢性腎臓病治療の柱の一つである適切な栄養管理を通したBMIに代表される体格の維持が、脳内酸素動態の維持とともに認知機能の維持・改善に働くことが明らかとなった。慢性腎臓病症例では、食塩およびたんぱく質の制限とともに適切なエネルギー摂取による体格の維持が認知機能障害の予防につながり、栄養指導の新たな重要性が示唆された。