2022 Fiscal Year Final Research Report
Inhibitory effects of medium-chain triglycerides in hepatocarcinogenesis and metaboic syndrome
| Project/Area Number |
20K11552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河野 寛 山梨大学, 大学院総合研究部, 特任准教授 (40322127)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 臓器マクロファージ / 肝類洞免疫 / 中鎖脂肪酸 / 肝発癌 / メタボリックシンドローム |
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| Outline of Final Research Achievements |
A diet supplemented with MCT was administered to an animal model of chemical hepatocarcinogenesis induced by DEN administration to examine the inhibitory effect of MCT on hepatocarcinogenesis. Minn mice were administered diethylnitroamine and fed MCT-added and normal diets. Mice were sacrificed and hepatocarcinogenesis was compared. Intra-abdominal adipose tissue findings were compared histopathologically using immunostaining. The expression of inflammatory cytokines and chemokines in the liver and intraperitoneal adipose tissue was examined. Cytokine and chemokine expression was suppressed in liver tissue. Chemo-hepatocarcinogenesis was significantly inhibited by MCT treatment due to the anti-inflammatory effect of anti-inflammatory cytokines in the local liver tissue and adipose tissue.
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| Free Research Field |
炎症免疫機構の解析
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| Academic Significance and Societal Importance of the Research Achievements |
化学物質誘発炎症性肝発癌は中鎖脂肪酸投与により有意に抑制された。その機序として、肝組織局所ならびに脂肪組織における抗炎症効果と考えられた。肝炎ウイルス感染に起因する肝発癌に減少傾向を認める中、現在、メタボリックシンドロームによるメタボリック肝発癌が急速に増加しており、その背景として、肝局所での炎症が原因となっている。今回の結果より中鎖脂肪酸の経口摂取によるメタボリックシンドロームの改善と肝発癌抑制が期待できる
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