2022 Fiscal Year Final Research Report
Prediction of physical function and metabolic risk by using distribution of trunk skeletal muscle and visceral fat
Project/Area Number |
20K11602
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 超音波画像 / 腹部骨格筋 / 腹腔内 / 皮下脂肪 / エコー強度 / インスリン抵抗性 |
Outline of Final Research Achievements |
There were sex differences in the association between nutritional status and quality indices in the trunk skeletal muscles of young adults. Namely, a significant positive correlation was found between the energy ratio of saturated fatty acids and echo intensity of trunk skeletal muscles only in young men. Sit-and-reach in men and arterial stiffness indices in women also showed significant correlations with echo intensities of trunk skeletal muscles. Cross-sectional and longitudinal studies revealed that the index of insulin resistance (HOMA-IR) in young men was significantly and positively correlated with trunk subcutaneous fat thickness, but not with intraabdominal thickness. In women, the ratio of the oblique abdominal muscles thickness to intraabdominal thickness was significantly and positively correlated with the index of insulin resistance.
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Free Research Field |
応用健康科学
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Academic Significance and Societal Importance of the Research Achievements |
一般に,メタボリックシンドロームなどの代謝疾患は,中年齢期以降における内臓脂肪の蓄積に伴い発症するものと認識されている.しかしながら,本研究で対象とした若年女性のうち20%において,インスリン抵抗性の指標が基準値を超えていた.また,若齢男性においては,内臓脂肪蓄積度の指標ではなく,皮下脂肪の量が,インスリン抵抗性と有意に関連していた.本研究の成果により,若年期から代謝疾患リスク低減にむけた取り組みを始めることの重要性が示唆された.また,超音波画像から評価した体幹部の骨格筋,皮下脂肪,腹腔内組織などの分布状況によりインスリン抵抗性の指標を評価可能となる可能性も示唆された.
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