2022 Fiscal Year Final Research Report
Development of a novel hemostatic device without blood coagulation factors utilizing micoroneedle technology
Project/Area Number |
20K12658
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 90120:Biomaterials-related
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Research Institution | Kindai University |
Principal Investigator |
Kato Nobuhiro 近畿大学, 生物理工学部, 教授 (60309268)
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Co-Investigator(Kenkyū-buntansha) |
田中 篤 和歌山県立医科大学, 医学部, 教授 (50458072)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | マイクロニードル / 止血 / 生分解性 / 3Dプリンタ |
Outline of Final Research Achievements |
Blood products used for hemostasis have a small but significant risk of infection. A novel device that can achieve hemostasis in a short time using non-biologically derived materials is needed. In this research project, we focused on microneedles (MN), which have been developed as a percutaneous drug delivery device. By applying an MN patch consisting of an array of microneedles to the surface of an organ that requires hemostasis during a surgical procedure, it is possible to promote hemostasis by physically immobilizing and holding the wound surface. Aiming to apply clinical application, we have established a method of increasing the size of the MN le patch and clarified the mechanical properties of the flexible mesh-like MN patch that does not inhibit organ movement.
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Free Research Field |
微細加工
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Academic Significance and Societal Importance of the Research Achievements |
従来の経皮薬剤送達用のマイクロニードル(MN)パッチでは全く考慮されてこなかった、パッチ基部の機械的な構造に着目した。新規の構造を考案し、パッチ基部に物理的な機能性を持たせることで、パッチの可撓性および伸展性を劇的に向上させる事に成功した。さらに光造形3Dプリンタによる原型作成およびFDM式3Dプリンタによるポリ乳酸メッシュシートの作成手法を確立した。これにより、大面積の止血用マイクロニードル(MN)パッチを迅速かつ安価に作成することが可能となった。
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