2022 Fiscal Year Final Research Report

Evaluation system of Dose Distribution in Boron Neutron Capture Therapy

Research Project

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Project/Area Number	20K12714
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 90140:Medical technology assessment-related
Research Institution	Okayama University
Principal Investigator	Igawa Kazuyo 岡山大学, 中性子医療研究センター, 准教授 (90512111)
Co-Investigator(Kenkyū-buntansha)	小川原亮京都大学, 化学研究所, 助教 (00807729) 泉健次新潟大学, 医歯学系, 教授 (80242436) 楠本多聞国立研究開発法人量子科学技術研究開発機構, 高度被ばく医療センター計測・線量評価部, 博士研究員(任常) (90825499)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	がん治療 / BNCT / ホウ素分布 / 固体飛跡検出器 / 線量評価
Outline of Final Research Achievements	Boron neutron capture therapy (BNCT) is a radiation cancer treatment based on (10B(n,α)7Li) reaction on a cancer cell by thermal neutron irradiation. The success of BNCT treatment depends on determining the neutron dose based on the distribution and concentration of boron-10 atoms in the tumor and normal tissues. In this study, we established a simple evaluation system of boron-10 tissue dose distribution using CR-39 nuclear track detector. Specially, the biological samples, such as cells and tissues of three-dimensional cancel models and tumor-bearing mice, containing boron-10 fixed to CR-39 by irradiation of thermal neutrons enabled the visualization of the boron-10 concentration as autoradiographs. These methods were applicable for evaluating the concentration of delivered boron -10 agents in the targeted tissue and cell and for assessment of absorbed dose. The results are expected to be applied clinically as boron accumulation tests and BNCT dosimetry before BNCT treatment.
Free Research Field	トランスレーショナルメディシン
Academic Significance and Societal Importance of the Research Achievements	本研究の組織内10B濃度分布評価法の確立により、患者ごとの10B濃度分布に基づいた線量計算が可能となり正確な処方中性子線量をBNCT治療計画で立案できる。組織内線量分布の評価体系の確立により「最善・最良」のがん治療となる頭頸部がんの組織系や部位を推奨できるようになり臨床意義がかなり高いといえる。さらに、新規薬剤10Bの開発、BNCT適応疾患拡大などBNCTの発展に大いに貢献できる。