Development of rapid photoresponsive molecular assemblies toward on-demand release of substances

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K15248
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 32020:Functional solid state chemistry-related
• Research Institution: Tottori University (2022); Tokyo University of Science (2020-2021)
• Principal Investigator: Akamatsu Masaaki 鳥取大学, 工学研究科, 講師 (70801182)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 界面活性剤 / 分子集合体 / 光応答 / 可溶化 / 放出制御

Outline of Final Research Achievements

o develop an on-demand delivery system that can release substances in the required amount at the desired timing, we evaluated the responsiveness of morphology of photoresponsive molecular assembly formed by amphiphilic lophine dimers and the ability to release model drugs. in situ small-angle neutron scattering (SANS) measurements revealed that the micelles formed by amphiphilic lophine dimers rapidly elongated and shrank with and without ultraviolet light irradiation. Furthermore, by using the rapid photoresponsive micelle, we successfully demonstrated rapidly controlled release model drugs, solubilized in the micelle.

Free Research Field

界面化学、超分子化学

Academic Significance and Societal Importance of the Research Achievements

本研究は、光刺激を利用した薬物放出システムの速度に着目し、その高速化に成功した初めての例である。分子を集合させるとフォトクロミック反応の反応率や速度が低下する従来の分子設計から脱却し、ロフィンダイマーの反応形式を逆手に取り、高速光応答性分子集合体の構築に成功した。オンデマンド性の高いドラッグデリバリーシステム（DDS）に限らず、その高速光応答性を生かした有効性成分の送達、濡れや接着性の制御、UVインク、光分子メモリ、光学材料などの開発にも本知見は活用できる。