Study of molecular mechanism in biofilm formation of Aeromonas spp.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16255
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49050:Bacteriology-related
• Research Institution: Hiroshima International University
• Principal Investigator: Seike Soshi 広島国際大学, 薬学部, 助教 (90806275)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: Aeromonas / Biofilm / バイオフィルム / 外膜小胞 / OMVs / 細胞毒性

Outline of Final Research Achievements

Previous study has shown that Aeromonas biofilm contain many outer membrane vesicles (OMVs), but their functions have been still unknown. In this study, it was found that the OMVs contained in biofilm facilitate biofilm formation. In addition, this study also revealed that the OMVs induced cytotoxicity to host cells. It is therefore considered that the OMVs released from Aeromonas involved in both bacterial survival and pathogenicity to host.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

本研究では，本菌が遊離するOMVsがAeromonasのbiofilm形成を促進するだけでなく，病原性発現にも関与していることを見出した．OMVsの作用は多岐にわたるが，その作用の詳細は未知な点が多い．本研究が更に進展し，菌とOMVsの相互作用，OMVsの宿主細胞に対する詳細な毒性メカニズム等が明らかになれば，感染症の克服の一助になると期待できる．