Multisensory integration in schizophrenia and autism spectrum disorder using magnetoencephalography

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16624
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Gifu University
• Principal Investigator: SUGIYAMA Shunsuke 岐阜大学, 大学院医学系研究科, 講師 (60755776)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 神経振動 / 脳磁計 / 聴性定常反応

Outline of Final Research Achievements

When this project began, the COVID-19 pandemic had already started, resulting in restricted access to research facilities and making it difficult to conduct experiments on patients. Therefore, the research focus had to be changed. I conducted neurophysiological studies on healthy individuals using the MEG at the National Institute for Physiological Sciences, where I had conducted research previously. I was particularly interested in neural oscillations and found that oscillations at around 20-30 Hz (beta to low gamma frequency band) were suppressed when the 40-Hz oscillation was activated. Similar findings were also revealed in another study that utilized the harmonic properties of oscillations. During the study period, I was the first author in four international journals.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

γ帯域（20-80 Hz）の神経振動であるγオシレーションは、様々な高次機能や精神疾患との関連があり注目されてきたが、固有の振動特性を持つ諸回路の個々の機能解明は十分ではなく、さらに、それぞれの回路間の相互作用についてはほとんど検討されていなかった。本研究は、ヒトにおいてγオシレーション間の相互作用を示した初めての研究となった。この研究は将来、精神疾患におけるγオシレーション異常の解明に繋がることが期待される。