Development of novel method for radiotheranostics using controlled drug release system

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16743
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kanazawa University (2021); Kobe Pharmaceutical University (2020)
• Principal Investigator: Munekane Masayuki 金沢大学, 薬学系, 助教 (80804806)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 核医学診断・治療 / リポソーム / 薬物放出制御 / ナノディスク

Outline of Final Research Achievements

We developed a novel drug release system, where drugs were released by morphological changes from “liposomes with an aqueous layer where hydrophilic drugs were encapsulated” to “nanodiscs without an aqueous layer”. The drug release rate can be controlled by the concentration of morphological changes accelerating compounds and lipid composition of liposomes. However, the drug release rate was extremely low in serum. Although specific reaction with liposomes and morphological changes accelerating compounds was tried by using click chemistry, improved drug release was not observed. New molecular design where the drug release is not inhibited by serum components is needed for practical use.

Free Research Field

分子イメージング

Academic Significance and Societal Importance of the Research Achievements

薬物放出制御法は、安価な低分子医薬品の体内動態を制御して薬効の増強、副作用の低減を可能とする優れた技術であり、新規薬物制御法の開発はわが国の医療福祉および医療経済に大きく貢献するものであり、本研究で得られた基礎的なデータは、新規薬物制御法の開発に貢献するものと期待される。また、本薬物放出制御法の核医学診断・治療への応用は、がんの精度の高い診断および安全性の高い治療を可能にする新規技術であり、わが国の医療福祉に貢献するものと期待される。