Clinical Usability of Free Breathing Three-Dimensional Late Gadolinium Enhancement Cardiovascular Magnetic Resonance using Compressed sensing

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K16761
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Ehime University
• Principal Investigator: NAKAMURA MASASHI 愛媛大学, 医学部附属病院, 助教(病院教員) (50794468)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 心臓MRI / Compressed Sensing

Outline of Final Research Achievements

In Cardiovascular Magnetic Resonance (CMR), late gadolinium enhancement (LGE) is an important tool in the assessment of Myocardial scar and fibrosis. A two-dimensional (2D) LGE sequence acquired in multiple breath-holds may suffer from slice misregistration and artifacts due to respiratory motion. Alternatively, a three-dimensional (3D) LGE sequence has been proposed with the potential advantage of isotropic resolution and extended myocardial coverage. The purpose of this study was to evaluate the diagnostic performance of free-breathing 3D LGE using CS (CS 3D LGE) comparing with conventional breath hold 2D LGE (2D LGE).
CS 3D LGE method allows complete whole heart coverage in a scan time of approximately 6 min while maintaining diagnostic performance. In clinical relevance, Free-breathing CS 3D LGE might be a suitable alternative to conventional breath hold 2D LGE for assessment of LGE for patients who cannot tolerate breath hold.

Free Research Field

心臓MRI

Academic Significance and Societal Importance of the Research Achievements

新たな高速撮像技術であるCompressed Sensing (CS)を併用した3D遅延造影撮像法（3D LGE）は、診断に十分評価可能な画質を維持したまま、従来の2D遅延造影撮像法（2D LGE）と比較して同等の遅延造影の診断能を有することが示唆された。本研究では検査時間の有意な短縮は得られなかったが、息止めなしの自由呼吸下で従来と同等の遅延造影画像を得られることは患者負担の軽減という点で大きなメリットになると思われる。