2022 Fiscal Year Final Research Report
Effects of maternal malnutrition on lung development, injury repair, and regeneration in newborn mouse lung
| Project/Area Number |
20K16902
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 新生児慢性肺疾患 / 子宮内胎児発育遅延 / 母体低栄養 |
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| Outline of Final Research Achievements |
We investigated the effect of maternal malnutrition on the development of severe bronchopulmonary dysplasia using mice models. No significant difference was observed in the expression of inflammatory cytokines between the maternal low-protein diet and control groups in the comparison of mRNA in the lungs. The expression of mRNA of insulin-like growth factor 1 is significantly higher in the lung of the maternal low-protein diet group than in the control group. The morphological assessment of the lungs showed no significant difference between the two groups. Although the pathohistological change of lung architecture was not observed, this study suggested that maternal malnutrition changed the growth hormone/insulin-like growth factor 1 pathway in the lungs.
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| Free Research Field |
新生児学
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| Academic Significance and Societal Importance of the Research Achievements |
母体低栄養が肺内での成長ホルモン/インスリン様成長因子1シグナリングに変化をもたらしていることが示された．新生児慢性肺疾患は発生途上の肺に種々の侵襲が加わることで，肺内で炎症と修復が繰り返されて発症する．母体低栄養は胎児にエピジェネティックな変化を起こすことが知られているが，肺の修復に関わるシグナルの変化はこれまでに知られていなかった．母体低栄養および子宮内胎児発育遅延が新生児慢性肺疾患の重症化に至る機序を解明する上で重要な知見であると考えられる．
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